XENE
Xenon Pharmaceuticals Inc. Healthcare - Biotechnology Investor Relations →
Xenon Pharmaceuticals Inc. (XENE) closed at $41.38 as of 2026-02-02, trading 9.0% above its 200-week moving average of $37.98. The stock moved further from the line this week, up from 8.1% last week. The 14-week RSI sits at 49, indicating neutral momentum.
Over the past 539 weeks of data, XENE has crossed below its 200-week moving average 5 times. On average, these episodes lasted 33 weeks. Historically, investors who bought XENE at the start of these episodes saw an average one-year return of +40.1%.
With a market cap of $3.2 billion, XENE is a mid-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -45.1%. The stock trades at 5.7x book value.
Share count has increased 48.0% over three years, indicating dilution.
Over the past 10.4 years, a hypothetical investment of $100 in XENE would have grown to $514, compared to $394 for the S&P 500. That represents an annualized return of 17.0% vs 14.1% for the index — confirming XENE as a market-beating investment and the kind of quality company where buying during 200-week moving average touches has historically been rewarded.
Free cash flow has been declining. A deteriorating cash flow trend warrants extra scrutiny — the stock may be cheap for a reason.
Growth of $100: XENE vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After XENE Crosses Below the Line?
Across 5 historical episodes, buying XENE when it crossed below its 200-week moving average produced an average return of +44.0% after 12 months (median +93.0%), compared to +17.5% for the S&P 500 over the same periods. 50% of those episodes were profitable after one year. After 24 months, the average return was +31.5% vs +42.5% for the index.
Each line shows $100 invested at the moment XENE crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
XENE has crossed below its 200-week MA 5 times with an average 1-year return of +40.1% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Oct 2015 | Jun 2018 | 141 | 73.5% | -10.5% | +348.3% |
| Dec 2018 | Jan 2019 | 5 | 26.2% | +90.8% | +466.1% |
| Mar 2025 | Apr 2025 | 4 | 16.7% | N/A | +20.8% |
| May 2025 | Aug 2025 | 14 | 19.7% | N/A | +18.2% |
| Sep 2025 | Sep 2025 | 1 | 1.4% | N/A | +14.3% |
| Average | 33 | — | +40.1% | — |
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of Friday close, 2026-02-02