OPK
OPKO Health, Inc. Healthcare - Diagnostics & Research Investor Relations →
OPKO Health, Inc. (OPK) closed at $1.12 as of 2026-03-20, trading 26.6% below its 200-week moving average of $1.53. This places OPK in the extreme value zone. The stock is currently moving closer to the line, down from -22.5% last week. With a 14-week RSI of 26, OPK is in oversold territory.
Trading volume is running at 1.2x of its 14-week average, which is in the normal range. The balance between buying and selling volume (0.89 ratio) is neutral — neither side is clearly dominating.
Over the past 1537 weeks of data, OPK has crossed below its 200-week moving average 26 times. On average, these episodes lasted 33 weeks. Historically, investors who bought OPK at the start of these episodes saw an average one-year return of +19.5%.
With a market cap of $860 million, OPK is a small-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -17.1%. The stock trades at 0.7x book value.
Over the past 29.5 years, a hypothetical investment of $100 in OPK would have grown to $41, compared to $1523 for the S&P 500. OPK has returned -3.0% annualized vs 9.7% for the index, underperforming the broader market over this period.
Free cash flow has been volatile over the past several years, making the quality of earnings harder to assess.
Business Health
Annual financials — how the underlying business has performed over the past several years.
Cash Flow Free cash flow & net income ($M)
Revenue Annual revenue ($M) — business growth proxy
Total Debt Balance sheet debt ($M)
ROIC Return on invested capital (%)
FCF Yield Free cash flow / market cap (%) — Yartseva signal
Gross Margin Pricing power & competitive moat (%)
Shares Outstanding Buybacks vs dilution (millions)
Growth of $100: OPK vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After OPK Crosses Below the Line?
Across 26 historical episodes, buying OPK when it crossed below its 200-week moving average produced an average return of +15.6% after 12 months (median +8.0%), compared to +12.4% for the S&P 500 over the same periods. 58% of those episodes were profitable after one year. After 24 months, the average return was +16.3% vs +20.6% for the index.
Each line shows $100 invested at the moment OPK crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
OPK has crossed below its 200-week MA 26 times with an average 1-year return of +19.5% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Oct 1996 | Aug 1997 | 43 | 40.2% | +137.0% | -66.8% |
| Aug 1997 | Sep 1997 | 3 | 5.2% | +79.3% | -69.1% |
| Aug 1998 | Sep 1998 | 2 | 28.7% | +86.9% | -70.6% |
| Oct 1998 | Oct 1998 | 2 | 6.6% | +25.6% | -77.6% |
| Nov 1998 | Dec 1998 | 3 | 9.2% | +15.5% | -78.7% |
| Jun 1999 | Jun 1999 | 1 | 3.5% | +41.7% | -79.5% |
| Apr 2000 | Apr 2000 | 1 | 22.0% | -21.2% | -77.9% |
| Dec 2000 | Jan 2001 | 3 | 3.7% | -67.0% | -84.3% |
| Jan 2001 | Aug 2006 | 291 | 92.9% | -67.7% | -84.9% |
| Jun 2008 | Jul 2008 | 2 | 16.2% | +37.8% | -11.8% |
| Sep 2008 | Jun 2009 | 37 | 64.3% | +53.1% | -22.8% |
| Jun 2009 | Jul 2009 | 3 | 11.1% | +25.7% | -36.0% |
| Nov 2009 | Apr 2010 | 19 | 19.8% | +80.8% | -34.9% |
| May 2010 | Jun 2010 | 6 | 12.6% | +100.5% | -40.1% |
| Jun 2010 | Jul 2010 | 1 | 0.2% | +69.1% | -49.1% |
| Aug 2010 | Oct 2010 | 8 | 8.2% | +78.8% | -48.4% |
| Jan 2016 | Feb 2016 | 6 | 10.5% | +11.2% | -86.4% |
| Jun 2016 | Jun 2016 | 1 | 2.9% | -27.8% | -87.6% |
| Aug 2016 | Sep 2016 | 2 | 4.9% | -32.8% | -87.7% |
| Oct 2016 | Nov 2016 | 5 | 4.3% | -26.5% | -88.1% |
| Dec 2016 | Jul 2020 | 185 | 77.0% | -47.3% | -88.0% |
| Aug 2020 | Oct 2020 | 6 | 30.3% | +15.6% | -66.5% |
| Oct 2020 | Nov 2020 | 4 | 13.0% | +7.7% | -68.2% |
| Jul 2021 | Aug 2021 | 1 | 0.4% | -31.4% | -67.4% |
| Jan 2022 | Mar 2022 | 7 | 11.5% | -57.3% | -62.0% |
| Apr 2022 | Ongoing | 205+ | 68.9% | Ongoing | -61.8% |
| Average | 33 | — | +19.5% | — |
Frequently Asked Questions
Is OPK below its 200-week moving average?
Yes. As of 2026-03-20, OPKO Health, Inc. (OPK) is trading 26.6% below its 200-week moving average of $1.53. The current price is $1.12.
What is OPK's 200-week moving average price?
OPKO Health, Inc.'s 200-week moving average is $1.53 as of 2026-03-20. This is the average weekly closing price over roughly the last 4 years, and it acts as a long-term trend line. When a stock drops below this level, it can signal that the price has fallen far enough from the long-term trend to attract value-oriented investors.
What happens when OPK drops below its 200-week moving average?
OPK has crossed below its 200-week moving average 26 times in our data. On average, buying at that moment produced a one-year return of +19.5%. These dips have historically been decent entry points. These episodes lasted 33 weeks on average.
Is OPK a good value right now?
Here's what our data says about OPK as of 2026-03-20: The stock is below its 200-week moving average, which is the starting point for our analysis. The 14-week RSI is 26 (oversold). Free cash flow is currently negative. Return on equity is -17.1%. Price-to-book is 0.7x. This is not a buy or sell recommendation — always do your own research.
How does OPK compare to the S&P 500?
Over the past 29.5 years, $100 invested in OPK would have grown to $41, compared to $1523 for the S&P 500. That's -3.0% annualized vs 9.7% for the index. OPK has underperformed the broader market over this period.
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of week of 2026-03-20