MDGL
Madrigal Pharmaceuticals, Inc. Healthcare - Biotechnology Investor Relations →
Madrigal Pharmaceuticals, Inc. (MDGL) closed at $477.60 as of 2026-02-02, trading 87.8% above its 200-week moving average of $254.30. The stock is currently moving closer to the line, down from 93.9% last week. The 14-week RSI sits at 58, indicating neutral momentum.
Over the past 943 weeks of data, MDGL has crossed below its 200-week moving average 15 times. On average, these episodes lasted 34 weeks. The average one-year return after crossing below was -4.7%, suggesting these dips have not historically been reliable buying opportunities for this stock.
With a market cap of $10.8 billion, MDGL is a large-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -41.2%. The stock trades at 17.3x book value.
Share count has increased 28.7% over three years, indicating dilution.
Over the past 18.2 years, a hypothetical investment of $100 in MDGL would have grown to $173, compared to $702 for the S&P 500. MDGL has returned 3.1% annualized vs 11.3% for the index, underperforming the broader market over this period.
In the past 12 months, corporate insiders have made 2 open-market purchases totaling $61,921,024.
Free cash flow has been declining. A deteriorating cash flow trend warrants extra scrutiny — the stock may be cheap for a reason.
Growth of $100: MDGL vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After MDGL Crosses Below the Line?
Across 15 historical episodes, buying MDGL when it crossed below its 200-week moving average produced an average return of +13.8% after 12 months (median +6.0%), compared to +9.7% for the S&P 500 over the same periods. 53% of those episodes were profitable after one year. After 24 months, the average return was +20.7% vs +26.9% for the index.
Each line shows $100 invested at the moment MDGL crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
MDGL has crossed below its 200-week MA 15 times with an average 1-year return of +-4.7% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Jan 2008 | Feb 2008 | 3 | 17.9% | +6.3% | +99.5% |
| Mar 2008 | Aug 2008 | 23 | 25.0% | -66.4% | +92.5% |
| Sep 2008 | Jan 2009 | 18 | 38.6% | -61.1% | +75.6% |
| Feb 2009 | Dec 2010 | 95 | 81.9% | -40.7% | +89.5% |
| Jan 2011 | Apr 2011 | 13 | 14.5% | -2.8% | +176.8% |
| Jun 2011 | Jan 2012 | 32 | 37.8% | +14.6% | +176.8% |
| Feb 2012 | May 2012 | 13 | 17.8% | +96.4% | +206.6% |
| Jun 2013 | Jul 2013 | 8 | 24.6% | -8.6% | +199.9% |
| Oct 2013 | Dec 2013 | 9 | 27.3% | -30.7% | +219.6% |
| Jan 2014 | Feb 2014 | 2 | 3.9% | -55.4% | +155.5% |
| Mar 2014 | Dec 2017 | 196 | 96.0% | -50.7% | +166.0% |
| Jan 2020 | Feb 2020 | 2 | 9.0% | +51.9% | +520.4% |
| Feb 2020 | May 2020 | 10 | 31.6% | +40.6% | +454.3% |
| May 2021 | Dec 2022 | 82 | 53.0% | -38.8% | +325.3% |
| Oct 2023 | Oct 2023 | 1 | 3.7% | +75.0% | +296.7% |
| Average | 34 | — | +-4.7% | — |
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of Friday close, 2026-02-02