LXRX
Lexicon Pharmaceuticals, Inc. Healthcare - Biotechnology Investor Relations →
Lexicon Pharmaceuticals, Inc. (LXRX) closed at $1.23 as of 2026-02-02, trading 26.8% below its 200-week moving average of $1.68. This places LXRX in the extreme value zone. The stock moved further from the line this week, up from -31.2% last week. The 14-week RSI sits at 47, indicating neutral momentum.
Over the past 1300 weeks of data, LXRX has crossed below its 200-week moving average 16 times. On average, these episodes lasted 67 weeks. The average one-year return after crossing below was -15.1%, suggesting these dips have not historically been reliable buying opportunities for this stock.
With a market cap of $514 million, LXRX is a small-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -45.9%. The stock trades at 3.7x book value.
Share count has increased 142.7% over three years, indicating dilution.
Over the past 25 years, a hypothetical investment of $100 in LXRX would have grown to $3, compared to $930 for the S&P 500. LXRX has returned -13.5% annualized vs 9.3% for the index, underperforming the broader market over this period.
In the past 12 months, corporate insiders have made 1 open-market purchase totaling $2,000,001. Notably, these purchases occurred while LXRX is trading below its 200-week moving average — insiders are buying when the market is most pessimistic.
Free cash flow has been declining. A deteriorating cash flow trend warrants extra scrutiny — the stock may be cheap for a reason.
Growth of $100: LXRX vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After LXRX Crosses Below the Line?
Across 16 historical episodes, buying LXRX when it crossed below its 200-week moving average produced an average return of -15.6% after 12 months (median -15.0%), compared to +10.8% for the S&P 500 over the same periods. 38% of those episodes were profitable after one year. After 24 months, the average return was -30.8% vs +20.9% for the index.
Each line shows $100 invested at the moment LXRX crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
LXRX has crossed below its 200-week MA 16 times with an average 1-year return of +-15.1% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Mar 2001 | Nov 2004 | 190 | 74.0% | +3.8% | -97.9% |
| Jan 2005 | Jan 2005 | 1 | 0.2% | -40.7% | -97.4% |
| Jan 2005 | Mar 2006 | 60 | 40.3% | -41.0% | -97.4% |
| Apr 2006 | Jan 2011 | 248 | 74.8% | -28.1% | -96.5% |
| Jan 2011 | Jan 2012 | 53 | 44.4% | -27.9% | -90.8% |
| May 2012 | May 2012 | 2 | 1.6% | +32.7% | -88.3% |
| Dec 2013 | Dec 2013 | 2 | 2.9% | -51.7% | -90.0% |
| Feb 2014 | Aug 2015 | 80 | 53.0% | -51.1% | -90.3% |
| Sep 2015 | Nov 2015 | 6 | 22.6% | +66.6% | -89.0% |
| Dec 2015 | Dec 2015 | 1 | 0.7% | +27.0% | -90.0% |
| Jan 2016 | Mar 2016 | 12 | 29.2% | +30.0% | -89.1% |
| May 2016 | May 2016 | 2 | 0.5% | +31.0% | -89.9% |
| Oct 2017 | May 2018 | 34 | 33.6% | -19.3% | -89.5% |
| Jul 2018 | Jan 2021 | 129 | 89.6% | -89.0% | -88.7% |
| Mar 2021 | Oct 2021 | 31 | 42.3% | -68.6% | -81.9% |
| Oct 2021 | Ongoing | 225+ | 84.7% | Ongoing | -75.9% |
| Average | 67 | — | +-15.1% | — |
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of Friday close, 2026-02-02