AXSM
Axsome Therapeutics Inc. Healthcare - Biotechnology Investor Relations →
Axsome Therapeutics Inc. (AXSM) closed at $182.55 as of 2026-02-02, trading 114.3% above its 200-week moving average of $85.17. The stock is currently moving closer to the line, down from 118.2% last week. With a 14-week RSI of 79, AXSM is in overbought territory.
Over the past 485 weeks of data, AXSM has crossed below its 200-week moving average 5 times. On average, these episodes lasted 34 weeks. Historically, investors who bought AXSM at the start of these episodes saw an average one-year return of +39.7%.
With a market cap of $9.2 billion, AXSM is a mid-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -275.5%. The stock trades at 124.5x book value.
Share count has increased 28.7% over three years, indicating dilution.
Over the past 9.4 years, a hypothetical investment of $100 in AXSM would have grown to $2875, compared to $378 for the S&P 500. That represents an annualized return of 42.9% vs 15.2% for the index — confirming AXSM as a market-beating investment and the kind of quality company where buying during 200-week moving average touches has historically been rewarded.
Free cash flow has been declining. A deteriorating cash flow trend warrants extra scrutiny — the stock may be cheap for a reason.
Growth of $100: AXSM vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After AXSM Crosses Below the Line?
Across 5 historical episodes, buying AXSM when it crossed below its 200-week moving average produced an average return of +52.4% after 12 months (median +48.0%), compared to +10.6% for the S&P 500 over the same periods. 80% of those episodes were profitable after one year. After 24 months, the average return was +91.0% vs +29.8% for the index.
Each line shows $100 invested at the moment AXSM crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
AXSM has crossed below its 200-week MA 5 times with an average 1-year return of +39.7% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Oct 2016 | Jan 2019 | 115 | 61.6% | -27.2% | +2557.2% |
| Aug 2021 | Oct 2021 | 9 | 43.0% | +102.4% | +698.6% |
| Oct 2021 | Aug 2022 | 41 | 48.5% | +9.9% | +374.2% |
| Sep 2022 | Oct 2022 | 5 | 13.8% | +56.6% | +309.1% |
| Nov 2023 | Nov 2023 | 2 | 4.4% | +56.9% | +217.9% |
| Average | 34 | — | +39.7% | — |
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of Friday close, 2026-02-02