ANAB
AnaptysBio, Inc. Healthcare - Biotechnology Investor Relations →
AnaptysBio, Inc. (ANAB) closed at $49.73 as of 2026-02-02, trading 101.4% above its 200-week moving average of $24.70. The stock moved further from the line this week, up from 92.9% last week. The 14-week RSI sits at 68, indicating neutral momentum.
Over the past 423 weeks of data, ANAB has crossed below its 200-week moving average 8 times. On average, these episodes lasted 37 weeks. The average one-year return after crossing below was -28.6%, suggesting these dips have not historically been reliable buying opportunities for this stock.
With a market cap of $1391 million, ANAB is a small-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -308.0%. The stock trades at -46.6x book value.
Share count has increased 10.2% over three years, indicating dilution.
Over the past 8.2 years, a hypothetical investment of $100 in ANAB would have grown to $47, compared to $278 for the S&P 500. ANAB has returned -8.7% annualized vs 13.3% for the index, underperforming the broader market over this period.
Free cash flow has been declining. A deteriorating cash flow trend warrants extra scrutiny — the stock may be cheap for a reason.
Growth of $100: ANAB vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After ANAB Crosses Below the Line?
Across 8 historical episodes, buying ANAB when it crossed below its 200-week moving average produced an average return of -29.4% after 12 months (median -34.0%), compared to +13.3% for the S&P 500 over the same periods. 14% of those episodes were profitable after one year. After 24 months, the average return was -24.0% vs +48.0% for the index.
Each line shows $100 invested at the moment ANAB crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
ANAB has crossed below its 200-week MA 8 times with an average 1-year return of +-28.6% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Dec 2018 | Dec 2018 | 2 | 13.7% | -71.3% | -10.2% |
| Mar 2019 | Mar 2019 | 1 | 1.3% | -71.4% | -22.0% |
| Jun 2019 | Jan 2024 | 239 | 83.7% | -62.3% | -16.1% |
| Feb 2024 | Feb 2024 | 1 | 2.5% | -36.6% | +116.1% |
| Mar 2024 | May 2024 | 9 | 16.6% | -28.7% | +112.1% |
| Jun 2024 | Jun 2024 | 3 | 2.2% | +1.2% | +112.2% |
| Oct 2024 | Jul 2025 | 36 | 47.3% | +68.7% | +129.4% |
| Aug 2025 | Sep 2025 | 8 | 15.9% | N/A | +136.5% |
| Average | 37 | — | +-28.6% | — |
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of Friday close, 2026-02-02