AXSM
Axsome Therapeutics Inc. Healthcare - Biotechnology Investor Relations →
Axsome Therapeutics Inc. (AXSM) closed at $156.92 as of 2026-03-20, trading 75.9% above its 200-week moving average of $89.20. The stock is currently moving closer to the line, down from 76.2% last week. The 14-week RSI sits at 55, indicating neutral momentum.
Trading volume is running at 1.1x of its 14-week average, which is in the normal range. The balance between buying and selling volume (1.17 ratio) is neutral — neither side is clearly dominating.
Over the past 491 weeks of data, AXSM has crossed below its 200-week moving average 5 times. On average, these episodes lasted 34 weeks. Historically, investors who bought AXSM at the start of these episodes saw an average one-year return of +39.7%.
With a market cap of $8.0 billion, AXSM is a mid-cap stock. Free cash flow yield is currently negative, meaning the company is burning cash. Return on equity stands at -252.1%. The stock trades at 90.4x book value.
Share count has increased 17.0% over three years, indicating dilution.
Over the past 9.5 years, a hypothetical investment of $100 in AXSM would have grown to $2471, compared to $356 for the S&P 500. That represents an annualized return of 40.2% vs 14.3% for the index — confirming AXSM as a market-beating investment and the kind of quality company where buying during 200-week moving average touches has historically been rewarded.
Free cash flow has been volatile over the past several years, making the quality of earnings harder to assess.
Business Health
Annual financials — how the underlying business has performed over the past several years.
Cash Flow Free cash flow & net income ($M)
Revenue Annual revenue ($M) — business growth proxy
Total Debt Balance sheet debt ($M)
ROIC Return on invested capital (%)
FCF Yield Free cash flow / market cap (%) — Yartseva signal
Gross Margin Pricing power & competitive moat (%)
Shares Outstanding Buybacks vs dilution (millions)
Growth of $100: AXSM vs S&P 500
Monthly data normalized to $100 at start. Vertical dashed lines mark 200-week MA touches.
What Happens After AXSM Crosses Below the Line?
Across 5 historical episodes, buying AXSM when it crossed below its 200-week moving average produced an average return of +52.4% after 12 months (median +48.0%), compared to +10.6% for the S&P 500 over the same periods. 80% of those episodes were profitable after one year. After 24 months, the average return was +91.0% vs +29.8% for the index.
Each line shows $100 invested at the moment AXSM crossed below its 200-week MA. Bold blue = stock average. Gray dashed = S&P 500 average over same periods.
Historical Touches
AXSM has crossed below its 200-week MA 5 times with an average 1-year return of +39.7% after recovery.
| Crossed Below | Recovered | Weeks | Max Depth | 1-Year Return | Return Since Touch |
|---|---|---|---|---|---|
| Oct 2016 | Jan 2019 | 115 | 61.6% | -27.2% | +2184.1% |
| Aug 2021 | Oct 2021 | 9 | 43.0% | +102.4% | +586.4% |
| Oct 2021 | Aug 2022 | 41 | 48.5% | +9.9% | +307.6% |
| Sep 2022 | Oct 2022 | 5 | 13.8% | +56.6% | +251.7% |
| Nov 2023 | Nov 2023 | 2 | 4.4% | +56.9% | +173.3% |
| Average | 34 | — | +39.7% | — |
Frequently Asked Questions
Is AXSM below its 200-week moving average?
No. Axsome Therapeutics Inc. (AXSM) is currently 75.9% above its 200-week moving average of $89.20. It would need to fall to $89.20 to cross below the line.
What is AXSM's 200-week moving average price?
Axsome Therapeutics Inc.'s 200-week moving average is $89.20 as of 2026-03-20. This is the average weekly closing price over roughly the last 4 years, and it acts as a long-term trend line. When a stock drops below this level, it can signal that the price has fallen far enough from the long-term trend to attract value-oriented investors.
What happens when AXSM drops below its 200-week moving average?
AXSM has crossed below its 200-week moving average 5 times in our data. On average, buying at that moment produced a one-year return of +39.7%. These dips have historically been decent entry points. These episodes lasted 34 weeks on average.
Is AXSM a good value right now?
Here's what our data says about AXSM as of 2026-03-20: The stock is above its 200-week moving average, so it doesn't currently meet our primary signal. The 14-week RSI is 55. Free cash flow is currently negative. Return on equity is -252.1%. Price-to-book is 90.4x. This is not a buy or sell recommendation — always do your own research.
How does AXSM compare to the S&P 500?
Over the past 9.5 years, $100 invested in AXSM would have grown to $2471, compared to $356 for the S&P 500. That's 40.2% annualized vs 14.3% for the index. AXSM has outperformed the broader market over this period.
Not financial advice. This is an educational tool. Past performance does not guarantee future results. Do your own research before making investment decisions.
Data as of week of 2026-03-20